Enteric preparation of ipecac alkaloids



JOSIAH IE. LILLY, 03E ILMDIAIHLPULI IlealLl-ihlil, .(arEiflIGNOR TO THE ELI LILLY AND COMPANY, U lNlIlllhlfl'l'tPUllIiih IiNlTlI/hlllh. ll, GOR'PDRATION OF INDIANA.

No llrawing.

amoebic and other torn 1s oi' dysentery. oral administration lor such purposes 1 been impracticable, however, because oi ts nauseating characteristics, except with he intervention oi an enteric coating, coverl i i ing, or container, and its use in such dis cases has been conih led largely to administ 'ation by injection in the to .n oi emetine, one oi its alkaloids. .l. h are discovered, however, that the alkaloid s or ipccao when pared by combining with Lloyds rea t, rollers earth, or other ellicient adsorbent agents, will carry the alkaloids through the ston'iach, which is normally acid, and yield them. up in the intestines, which are normally alkaline, thus passing the medicine into the circulation where it exerts its reincdial eid'ect without causing eniesis or nausea.

My invention consists, therefore, in an entcric medicinal preparation containinggau alkaloid or alkaloids oi ipecac in a form to pass through the stomach without einesis or nausea and be released. into the circulation through the agency of the allnilinc secretions oi the intestines.

The process of making this compound while capable of modification and variation in details, may be described substantially as tollows:

The drug ipecac properly ground or comininuted is exhausted, as by percolation, with water containing one per cent. oi? sullt'uric or other appropriate acid. To this percolate is added in proper proportionate quantities hydrated aluminum or magnesium silicate, or any other insoluble adsorbing; agent which may be found etlicient. The alkaloids oi ipccac are thus adsorbed and separated from the supernatant liquid by allowing; to settle, decantatine; and straining, the resulting combination of the alkaloids with the adsorbing agent is then dried Specification of Letters Patent.

Application filed August 14,-. 1M5.

.rrncno amranorns.

ilatented Mar. 23, 1920.

Serial No. 4am.

and assayed as to the alkaloidal content. .lt is then brought by appropriate methods to a lined shandard oil. alkaloidal content and neparc in form for convenient administration, such tablet capsule :t'orn'i, each tablet or c.. psule containing a definite. quantity or the alkaloid or alkaloic In such :t'orm the niedicina capable olr' administration throun'h the .n'ith, without the interwail-ion oi? any coating or covering and without causing nausea or eznesis and the remedial action of the medicine is immediately begun and exerted through the circulation as before mentioned.

It will be understood that this invention includes the use oi any, some or all of the alkaloir oi ipecac, or any oi their derivatives found appropriate for the purpose.

I use the term adsorbent in this disclosure to define a substance so combining with the alkaloids ol' .ipccac that in. acid mediuni said alkaloids are prevented from rurtering into solution but are rendered. capable oi? entering into solution when placed in an alkaline medium; to illustrate, when present in the stomach, which is usualh acid, the alkaloids oi ipecac are retained by this adsorbent, but as it passes from the stomach into the intestines, which are usually alkaline, the alkaloids are gradually separated from the adsorbent.

.llaving thus described my said invention, what l claim. is:

I l, A medicinal preparation comprising d *l'lltltlVGS of ipecao alkaloids and an ad- 'beut substance which is adapted to carry mild derivatives through the stoi'uach and yield them up in the intestines.

an. medicinal preparation coniprisiiw' alkaloids of Tpecac and an adsorbent aceiilz adapted to carry said alkaloid illlfOllfIli tllfi stomach and yield it up to the circulaiien through the agency of the alkaline secretions of the intestines.

3. .d. in :inal preparation. including; derivatives of ipecac alkaloids combined with an adsorbent agent adapted to carry them through the stomach, prepared in. uncovered tablet form.

4t. A medicinal preparation containing alkaloids of ipecac combined with an adsorbent agent capable to prevent the solution and absorption of alkaloid in the acid medium of the stomach and to release said :11-

kaloid in the alkaline medium of the inmy hand and seal at Indianapolis, Indiana, testines. this 11th day of Aug, A. D. nineteen hun- 5. A medicinal preparatioln 1501i internal dred and fifteen. administration containing a1 aloics of ipe T '5 cao combined With aluminum silicate as an JOSIAH LILLX adsorbent agent. Witness:

In Witness whereof I have hereunto set E. W'. BRADFORD. 

